PhD in Biomedical Engineering

The objective was to find predictive markers of acquired disability in multiple sclerosis.

The original title is:

Methodological development for the absolute and multi-tissue quantification in magnetic resonance spectroscopy of metabolic alterations in multiple sclerosis.

My work involved several scientific fields:

• data fusion of image processing (segmentation and registration) and signal processing (non-linear regression) algorithms to provide spatial measurements of innovative biomarkers from magnetic resonance spectroscopy.
• methodological developments in a clinical context (calibrations, corrections, variability assessments) to obtain quantitative and reliable data and allow comparisons between patients and examinations
• Biostatistics to answer medical questions on longitudinal cohorts

The main achievements were:

• participation in international scientific congresses (Hawaii and Montréal)
• 3 months as a scientific visitor at McGill University (Montréal), in the McConnell Brain Imaging Centre https://www.mcgill.ca/bic/
• publication of a scientific article in the peer-reviewed journal IEEE Transactions on Medical Imaging https://ieeexplore.ieee.org/document/5951742?reload=true&arnumber=5951742

The scientific part of the doctorate was supervised by CREATIS  https://www.creatis.insa-lyon.fr/, a research lab specialized in medical image processing and MRI acquisition.

The medical part of the doctorate was supervised by Pr. Confavreux's team from Lyon neurological hospital, which specialized in multiple sclerosis.

My daily work took place within CERMEP https://www.cermep.fr/, a clinical and research medical imaging platform inside the Lyon hospital.

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