The objective was to find predictive markers of acquired disability in multiple sclerosis.
The original title is:
Methodological development for the absolute and multi-tissue quantification in magnetic resonance spectroscopy of metabolic alterations in multiple sclerosis.
My work involved the use of several scientific fields:
- data fusion of image processing (segmentation and registration) and signal processing (non-linear regression) algorithms to provide spatial measurements of innovative biomarkers from magnetic resonance spectroscopy.
- methodological developments in clinical context (calibrations, corrections, variability assessments) to obtain quantitative and reliable data and allow comparisons between patients and examinations
- biostatistics to answer medical questions on longitudinal cohorts
The main achievements were:
- participation in international scientific congresses (Hawaii and Montréal)
- 3 months as a scientific visitor at McGill University (Montréal), in the McConnell Brain Imaging Centre https://www.mcgill.ca/bic/
- publication of a scientific article in the peer-reviewed journal IEEE Transaction in Medical Imaging https://ieeexplore.ieee.org/document/5951742?reload=true&arnumber=5951742
The scientific part of the doctorate was supervised by CREATIS https://www.creatis.insa-lyon.fr/, a research lab specialized in medical image processing and MRI acquisition.
The medical part of the doctorate was supervised by Pr. Confavreux team from Lyon neurological hospital, specialized in multiple sclerosis.
My daily work took place within CERMEP https://www.cermep.fr/, a clinical and research medical imaging platform inside the Lyon hospital.